Tools are accessed from the Toolbar.
This is a general introduction to tools, individual tools have their own documentation.
There can only be one active tool which is stored for each space & mode.
Tools may set their own keys which override other keys although typically they use the LMB, sometimes with modifier keys. Keymaps can be edited from the preferences.
Some tools define gizmos (Shear and Spin for example) to help control the tool.
The Toolbar shows buttons for each tool. For tool buttons which have a small triangle in their bottom right corner, a pop-up menu will be revealed when you LMB drag so that you can select other tools of the same group.
Hovering your cursor over a tool for a short time will show its name, while hovering longer will show the full tooltip.
Resizing the Toolbar horizontally will display the icons with two columns. Expanding it further will display the icon and its text.
Pressing Alt opens a tool prompt, shown in the Status Bar, for changing the active tool, pressing Alt again closes the prompt.
Tools can be changed by pressing the appropriate icon or by pressing Alt then pressing the hotkey assigned to the desired tool.
Keyboard tool switching is not enabled by default. To enable it, set the Keymap preferences Spacebar Action to Tools, and then you’ll be able use Spacebar like a modifier key (similar to pressing Ctrl or Shift).
Spacebar T for Transform, Spacebar D for Annotate, Spacebar M for measure, etc.
The Quick Favorites menu gather your favorite tools. Any tool or menu can be added to this pop-up menu via the context menu of buttons and menus.
The fallback tool is the default tool in the Toolbar as in the tool at the top of the list. To switch to this tool use Alt-W to open a pie menu to choose what the default drag action does.
If you bind a key to a tool which is part of a group, you can enable the Cycle option in the keymap editor. Successive presses will cycle through the tools in that group.
Tools can have their own settings, which are available from multiple places:
The Active Tool tab in the Properties editor.
The Tool Settings region.